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Edward and Alphonse Elric are two alchemists brothers who search for the legendary Philosopher's Stone, a powerful object which would allow them to recover their bodies (which were lost in an attempt to bring their mother back to life through alchemy). Being born in the village of Resembool from the country of Amestris, the two brothers lived there with their parents. Their father, Hohenheim, left home for unknown reasons and years later, their mother, Trisha Elric, died of a terminal illness leaving the Elric brothers alone. After their mother's death, Edward becomes determined to bring her back through the use of alchemy, an advanced science in which objects can be created from raw materials. They researched Human Transmutation, a forbidden art in which one attempts to create or modify a human being. However, this attempt failed, ultimately resulting in the loss of Edward's left leg and Alphonse's entire body. In a desperate effort to save his brother, Edward sacrificed his right arm to affix his brother's soul to a suit of armour. Source at Wikipedia

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